Overview

  • Product name

    Streptozocin, Pancreatic beta-cell toxin
  • Description

    Selective pancreatic β-cell toxin
  • Biological description

    Selective pancreatic β-cell toxin. DNA alkylating agent. Diabetagen and anticancer activity in vivo.
  • Purity

    > 95%
  • CAS Number

    18883-66-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino-D-glucose
  • Molecular weight

    265.22
  • Molecular formula

    C8H15N3O7
  • PubChem identifier

    7067772
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O)N=O
  • Source

    Stretomyces achromogenes

  • Research areas

References

This product has been referenced in:

  • Choi SA  et al. Differential gene expression in pancreatic tissues of streptozocin-induced diabetic rats and genetically-diabetic mice in response to hypoglycemic dipeptide cyclo (His-Pro) treatment. Mol Biol Rep 39:8821-35 (2012). Read more (PubMed: 22707198) »
  • Szkudelski T The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50:537-46 (2001). Read more (PubMed: 11829314) »
  • Moertel CG  et al. Streptozocin alone compared with streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma. N Engl J Med 303:1189-94 (1980). Read more (PubMed: 6252466) »

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