Strychnine hydrochloride, Glycine antagonist (ab120416)
Key features and details
- Glycine antagonist
- CAS Number: 1421-86-9
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Strychnos sp.
Overview
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Product name
Strychnine hydrochloride, Glycine antagonist -
Description
Glycine antagonist -
Biological description
Competitive glycine receptor antagonist. Convulsant. Also antagonist at α7 receptors and α4β2 nicotinic receptors.
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CAS Number
1421-86-9 -
Chemical structure
Properties
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Chemical name
Strychnidin-10-one hydrochloride -
Molecular weight
370.87 -
Molecular formula
C21H22N2O2.HCl -
PubChem identifier
16219987 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C2C[C@@H]7OCC=C6CN4CC[C@@]53c1ccccc1N2C3[C@H]7[C@H]6C[C@H]45 -
Source
Strychnos sp.
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (27)
ab120416 has been referenced in 27 publications.
- Martín-de-Saavedra MD et al. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron 110:627-643.e9 (2022). PubMed: 34921780
- Huang DF et al. Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons. Proc Natl Acad Sci U S A 119:e2203632119 (2022). PubMed: 35951651
- Guo C et al. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. Elife 10:N/A (2021). PubMed: 34369877
- Khan MM & Regehr WG Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions. Elife 9:N/A (2020). PubMed: 32347796
- St Laurent R et al. Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity. Neuron 106:624-636.e4 (2020). PubMed: 32191871