Key features and details
- Glycine antagonist
- CAS Number: 1421-86-9
- Purity: > 99%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Strychnos sp.
Product nameStrychnine hydrochloride, Glycine antagonist
Competitive glycine receptor antagonist. Convulsant. Also antagonist at α7 receptors and α4β2 nicotinic receptors.
Chemical nameStrychnidin-10-one hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120416 has been referenced in 21 publications.
- Khan MM & Regehr WG Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions. Elife 9:N/A (2020). PubMed: 32347796
- Raja MK et al. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Elife 8:N/A (2019). PubMed: 31090538
- Breton-Provencher V & Sur M Active control of arousal by a locus coeruleus GABAergic circuit. Nat Neurosci 22:218-228 (2019). PubMed: 30643295
- Brownjohn PW et al. Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. Stem Cell Reports 8:870-882 (2017). PubMed: 28285880
- Chiu SL et al. GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron 93:1405-1419.e8 (2017). PubMed: 28285821