Anti-Sts1 antibody (ab155307)
Key features and details
- Rabbit polyclonal to Sts1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Sts1 antibody
See all Sts1 primary antibodies -
Description
Rabbit polyclonal to Sts1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 117-649 of Human Sts1.
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Positive control
- Jurkat and THP-1 whole cell lysates; Human hepatoma tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab155307 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 73 kDa.
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IHC-P |
1/100 - 1/1000.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 73 kDa. |
IHC-P
1/100 - 1/1000. |
Target
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Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. -
Sequence similarities
Contains 1 SH3 domain.
Contains 1 UBA domain. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 84959 Human
- Omim: 609201 Human
- SwissProt: Q8TF42 Human
- Unigene: 444075 Human
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Alternative names
- Cbl interacting protein p70 antibody
- Cbl interacting protein Sts 1 antibody
- Cbl interacting protein Sts1 antibody
see all
Images
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All lanes : Anti-Sts1 antibody (ab155307) at 1/5000 dilution
Lane 1 : Jurkat whole cell lysate
Lane 2 : THP-1 whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 73 kDa
7.5% SDS PAGE -
Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue, labeling Sts1 with ab155307 at 1/500 dilution.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab155307 has been referenced in 2 publications.
- Ye DJ et al. Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells. Biomol Ther (Seoul) 25:321-328 (2017). PubMed: 27956712
- Shin S et al. Human steroid sulfatase induces Wnt/ß-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1a in human prostate and cervical cancer cells. Oncotarget 8:61604-61617 (2017). PubMed: 28977889