Key features and details
- Rabbit polyclonal to STX11
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-STX11 antibody
See all STX11 primary antibodies
DescriptionRabbit polyclonal to STX11
Specificityab216046 detects endogenous level of total STX11 protein.
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Fusion protein corresponding to Human STX11 aa 1-287. Full length fusion protein: The identity of the protein fusion partner is GST
MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRD IQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVI HCKLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAE MKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGA RAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQ KTVDYTGQAKAQVRKAVQYEEKNPCRTLCCFCCPCLK
Database link: O7555
- Mouse lung tissue lysate. Human thyroid cancer tissue.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab216046 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/400 - 1/2000. Predicted molecular weight: 33 kDa.|
|IHC-P||1/25 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionSNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
Involvement in diseaseDefects in STX11 are the cause of hemophagocytic lymphohistiocytosis familial type 4 (FHL4) [MIM:603552]; also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T lymphocytes in lymph nodes, spleen, and other organs is also found.
Sequence similaritiesBelongs to the syntaxin family.
Contains 1 t-SNARE coiled-coil homology domain.
Cellular localizationMembrane. Golgi apparatus > trans-Golgi network membrane.
- Information by UniProt
- FHL4 antibody
- HLH4 antibody
- HPLH4 antibody
ab216046 has not yet been referenced specifically in any publications.