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    stx11-antibody-ab69828.pdf

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Anti-STX11 antibody (ab69828)

  • Datasheet
  • SDS
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Western blot - Anti-STX11 antibody (ab69828)
  • Western blot - Anti-STX11 antibody (ab69828)

Key features and details

  • Mouse polyclonal to STX11
  • Suitable for: WB
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human STX11 protein (denatured) (ab126662)
Secondary
Product image
Goat Anti-Mouse IgG H&L (HRP) (ab205719)

View more associated products

Overview

  • Product name

    Anti-STX11 antibody
    See all STX11 primary antibodies
  • Description

    Mouse polyclonal to STX11
  • Host species

    Mouse
  • Tested Applications & Species

    Application Species
    WB
    Human
    See all applications and species data
  • Immunogen

    STX11 (NP_003755.2, 1 a.a. ~ 287 a.a) full-length human protein.

  • Positive control

    • Human spleen and STX11 transfected 293T cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.4
    Constituent: 2.68% PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • Endosome
    • Signal Transduction
    • Protein Trafficking
    • Vesicle Transport
    • SNAPs & SNAREs
    • Signal Transduction
    • Protein Trafficking
    • Vesicle Transport
    • Regulation

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG - Isotype Control (ab37355)
  • Recombinant Protein

    • Recombinant Human STX11 protein (denatured) (ab126662)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab69828 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
WB
Human
Application Abreviews Notes
WB
1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).
Notes
WB
1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

Target

  • Function

    SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
  • Involvement in disease

    Defects in STX11 are the cause of hemophagocytic lymphohistiocytosis familial type 4 (FHL4) [MIM:603552]; also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T lymphocytes in lymph nodes, spleen, and other organs is also found.
  • Sequence similarities

    Belongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Cellular localization

    Membrane. Golgi apparatus > trans-Golgi network membrane.
  • Target information above from: UniProt accession O75558 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 8676 Human
    • Omim: 605014 Human
    • SwissProt: O75558 Human
    • Unigene: 118958 Human
    • Alternative names

      • FHL4 antibody
      • HLH4 antibody
      • HPLH4 antibody
      • Stx11 antibody
      • STX11_HUMAN antibody
      • Syntaxin 11 antibody
      • Syntaxin-11 antibody
      see all

    Images

    • Western blot - Anti-STX11 antibody (ab69828)
      Western blot - Anti-STX11 antibody (ab69828)
      Anti-STX11 antibody (ab69828) at 1/500 dilution + human spleen lysate at 25 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size: 33 kDa
      Observed band size: 31 kDa why is the actual band size different from the predicted?
      Additional bands at: 28 kDa. We are unsure as to the identity of these extra bands.

    • Western blot - Anti-STX11 antibody (ab69828)
      Western blot - Anti-STX11 antibody (ab69828)
      All lanes : Anti-STX11 antibody (ab69828) at 1/500 dilution

      Lane 1 : STX11 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size: 33 kDa
      Observed band size: 33 kDa

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab69828? Please let us know so that we can cite the reference in this datasheet.

    ab69828 has been referenced in 2 publications.

    • Hellewell AL  et al. Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells. PLoS One 9:e98900 (2014). Human . PubMed: 24910990
    • Izbicka E  et al. Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women. Cancer Genomics Proteomics 9:27-35 (2012). WB ; Human . PubMed: 22210046

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