Overview

  • Product name

    SU 11274, Met inhibitor
  • Description

    Potent, selective cell-permeable Met inhibitor
  • Biological description

    Potent, selective Met inhibitor (IC50 = 20 nM). Anticancer activity in vivo. Cell-permeable.
  • Purity

    > 98%
  • CAS Number

    658084-23-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kenessey I  et al. Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma. Curr Cancer Drug Targets 10:332-42 (2010). Read more (PubMed: 20370683) »
  • Seiwert TY  et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res 69:3021-31 (2009). Read more (PubMed: 19318576) »
  • Sattler M  et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res 63:5462-9 (2003). Read more (PubMed: 14500382) »

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