Overview

  • Product name

    SU 1498, VEGFR2 inhibitor
  • Description

    Selective VEGFR2 inhibitor
  • Biological description

    Selective VEGFR-2 inhibitor (IC50 = 700 nM). Shows antiangiogenic activity. Active in vivo.

  • Purity

    > 99%
  • General notes

    It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 1 hour a DMSO solution showed signs of decomposition. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately

  • CAS Number

    168835-82-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kisielewska J  et al. The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145). Folia Histochem Cytobiol 46:185-91 (2008). Read more (PubMed: 18519236) »
  • Cebulla CM  et al. Lack of effect of SU1498, an inhibitor of vascular endothelial growth factor receptor-2, in a transgenic murine model of retinoblastoma. Open Ophthalmol J 2:62-7 (2008). Read more (PubMed: 19517030) »
  • Wang Y  et al. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol 283:C1540-7 (2002). Read more (PubMed: 12372815) »
See all 3 Publications for this product

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