- References (3)
Product nameSU 1498, VEGFR2 inhibitor
DescriptionSelective VEGFR2 inhibitor
Selective VEGFR-2 inhibitor (IC50 = 700 nM). Shows antiangiogenic activity. Active in vivo.
It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 1 hour a DMSO solution showed signs of decomposition. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100 mM
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Kisielewska J et al. The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145). Folia Histochem Cytobiol 46:185-91 (2008). Read more (PubMed: 18519236) »
- Cebulla CM et al. Lack of effect of SU1498, an inhibitor of vascular endothelial growth factor receptor-2, in a transgenic murine model of retinoblastoma. Open Ophthalmol J 2:62-7 (2008). Read more (PubMed: 19517030) »
- Wang Y et al. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol 283:C1540-7 (2002). Read more (PubMed: 12372815) »