Key features and details
- Potent, selective VEGFR and FGFR inhibitor
- CAS Number: 215543-92-3
- Purity: > 98%
- Supplied in DMSO (10 mM)
- Form / State: Solid
- Source: Synthetic
Product nameSU-5402 (DMSO solution), VEGFR and FGFR inhibitor
DescriptionPotent, selective VEGFR and FGFR inhibitor
Potent, selective VEGFR and FGFR inhibitor (IC50 values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo.
Also available as a solid (ab141368).
Chemical name3-[4-Methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSupplied in DMSO (10 mM)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146602 has been referenced in 1 publication.
- Antonica F et al. Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. Dev Biol 450:132-140 (2019). PubMed: 30940540