Overview

  • Product name

    SU-5402, VEGFR and FGFR inhibitor
  • Description

    Potent, selective VEGFR and FGFR inhibitor
  • Biological description

    Potent, selective VEGFR and FGFR inhibitor (IC50 values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo.
  • Purity

    > 97%
  • CAS Number

    215543-92-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jandzik D  et al. Roles for FGF in lamprey pharyngeal pouch formation and skeletogenesis highlight ancestral functions in the vertebrate head. Development 141:629-38 (2014). Read more (PubMed: 24449839) »
  • Hasse C  et al. FGFR-ERK signaling is an essential component of tissue separation. Dev Biol 395:154-66 (2014). Read more (PubMed: 25149325) »
  • Li Y  et al. FGF23 affects the lineage fate determination of mesenchymal stem cells. Calcif Tissue Int 93:556-64 (2013). Read more (PubMed: 24068282) »
See 1 Publication for this product

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