Overview

  • Product name

    SU 6668, PDGFR inhibitor
  • Description

    Potent PDGFR inhibitor
  • Biological description

    Potent PDGFRβ inhibitor (IC50 = 60 nM). Also inhibits VEGFR2 and FGFR1 (IC50 values are 2 and 3 μM respectively). Antiproliferative effects in vitro. Anticancer and proapoptotic activity in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    252916-29-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Klenke FM  et al. Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo. BMC Cancer 7:49 (2007). Read more (PubMed: 17367541) »
  • Laird AD  et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 60:4152-60 (2000). Read more (PubMed: 10945623) »
  • Sun L  et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem 42:5120-30 (1999). Read more (PubMed: 10602697) »

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