Overview

  • Product name

    SU4312, VEGFR and PDGFR receptor tyrosine kinase inhibitor
  • Description

    Potent, selective VEGFR and PDGFR receptor tyrosine kinase inhibitor
  • Biological description

    Potent, selective VEGFR and PDGFR tyrosine kinases inhibitor (IC50 values are 0.8 and 19.4 μM respectively). Shows anti-angiogenic effects. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    5812-07-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Cui W  et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol 168:1201-14 (2013). Read more (PubMed: 23062100) »
  • Tran TC  et al. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res 67:11386-92 (2007). Read more (PubMed: 18056466) »
  • Schultheiss C  et al. In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease. Angiogenesis 9:59-65 (2006). Read more (PubMed: 16821113) »
  • Sun L  et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem 42:5120-30 (1999). Read more (PubMed: 10602697) »

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