Suberoyl bis-hydroxamic acid (SBHA), HDAC inhibitor (ab144532)

Overview

  • Product name

    Suberoyl bis-hydroxamic acid (SBHA), HDAC inhibitor
  • Description

    Potent, non-selective HDAC inhibitor
  • Biological description

    Potent, non-selective HDAC inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC50 = 15 μM, HeLa cells).
  • Purity

    > 98%
  • CAS Number

    38937-66-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • You BR & Park WH Suberoyl bishydroxamic acid-induced apoptosis in HeLa cells via ROS-independent, GSH-dependent manner. Mol Biol Rep 40:3807-16 (2013). Read more (PubMed: 23269626) »
  • Dasmahapatra G  et al. The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood 115:4478-87 (2010). Read more (PubMed: 20233973) »
  • Adler JT  et al. Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors. Ann Surg Oncol 16:481-6 (2009). Read more (PubMed: 19030935) »

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