Recombinant Anti-Substance P antibody [EPR3959] (ab133240)

Rabbit recombinant monoclonal Substance P antibody [EPR3959]. Validated in IHC and tested in Human.


  • Product name

    Anti-Substance P antibody [EPR3959]
    See all Substance P primary antibodies
  • Description

    Rabbit monoclonal [EPR3959] to Substance P
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
    Unsuitable for: ICC/IF
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Substance P aa 50 to the C-terminus. The exact sequence is proprietary.
    Database link: P20366

  • Positive control

    • Human brain tissue
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab133240 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/250 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

For unpurified, use 1/50 - 1/100.

  • Application notes
    Is unsuitable for ICC/IF.
  • Target

    • Function

      Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
    • Sequence similarities

      Belongs to the tachykinin family.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • C-terminal-flanking peptide antibody
      • Hs.2563 antibody
      • neurokinin 1 antibody
      • neurokinin 2 antibody
      • neurokinin A antibody
      • neurokinin alpha antibody
      • Neuromedin L antibody
      • neuropeptide gamma antibody
      • neuropeptide K antibody
      • NK2 antibody
      • NKA antibody
      • NKNA antibody
      • NPK antibody
      • PPT antibody
      • preprotachykinin antibody
      • protachykinin antibody
      • protachykinin-1 antibody
      • Substance K antibody
      • SubstanceP antibody
      • TAC1 antibody
      • TAC2 antibody
      • TAC2, formerly antibody
      • Tachykinin 1 antibody
      • tachykinin 2 antibody
      • tachykinin 2, formerly antibody
      • Tachykinin precursor 1 antibody
      • tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) antibody
      • Tachykinin1 antibody
      • TKN1_HUMAN antibody
      see all


    • Immunohistochemical staining of paraffin embedded human cerebral cortex with purified ab133240 at a working dilution of 1 in 250. The secondary antibody used is a HRP goat anti-rabbit (ab97051). The sample is counter-stained with hematoxylin. Antigen retrieval was perfomed using Tris-EDTA buffer, pH 9.0. PBS was used instead of the primary antibody as the negative control, and is shown in the inset.

    • Immunohistochemical analysis of Substance P in paraffin embedded human brain tissue, using unpurified ab133240 at a 1/50 dilution.


    This product has been referenced in:

    • Nishijima H  et al. Denervation of nasal mucosa induced by posterior nasal neurectomy suppresses nasal secretion, not hypersensitivity, in an allergic rhinitis rat model. Lab Invest 96:981-93 (2016). Read more (PubMed: 27322954) »
    See 1 Publication for this product

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