Overview

  • Product name
    Sulbactam
  • Description
    Competitive, irreversible β-lactamase inhibitor
  • Biological description
    Competitive, irreversible β-lactamase inhibitor (IC50 = 0.02 -1.9 μM). Improves the efficacy of β-lactam antibiotics against resistant strains. Active in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Molecular weight
    233.24
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C8H11NO5S
  • CAS Number
    68373-14-8
  • PubChem identifier
    130313
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Appelbaum PC  et al. Characterization of beta-lactamases from non-Bacteroides fragilis group Bacteroides spp. belonging to seven species and their role in beta-lactam resistance. Antimicrob Agents Chemother 34:2169-76 (1990). Read more (PubMed: 2073107) »
  • Bush K Beta-lactamase inhibitors from laboratory to clinic. Clin Microbiol Rev 1:109-23 (1988). Read more (PubMed: 3060240) »
  • Yamaguchi A  et al. Kinetic studies on inactivation of Citrobacter freundii cephalosporinase by sulbactam. Antimicrob Agents Chemother 24:23-30 (1983). Read more (PubMed: 6312873) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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