Overview

  • Product name

    Sulbactam sodium salt, beta-lactamase inhibitor
  • Description

    Irreversible β-lactamase inhibitor
  • Biological description

    Irreversible β-lactamase inhibitor (IC50 = 0.02 - 1.9 μM). Increases the activity of β-lactam antibiotics. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    69388-84-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4?6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate sodium salt
  • Molecular weight

    255.22
  • Molecular formula

    C8H10NNaO5S
  • PubChem identifier

    23663973
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Papp-Wallace KM  et al. Inactivation of a class A and a class C ß-lactamase by 6ß-(hydroxymethyl)penicillanic acid sulfone. Biochem Pharmacol 83:462-71 (2012). Read more (PubMed: 22155308) »
  • Rodkey EA  et al. Crystal structure of a preacylation complex of the ß-lactamase inhibitor sulbactam bound to a sulfenamide bond-containing thiol-ß-lactamase. J Am Chem Soc 134:16798-804 (2012). Read more (PubMed: 22974281) »
  • Swarén P  et al. X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid. Biochemistry 38:9570-6 (1999). Read more (PubMed: 10423234) »
  • Appelbaum PC  et al. Characterization of beta-lactamases from non-Bacteroides fragilis group Bacteroides spp. belonging to seven species and their role in beta-lactam resistance. Antimicrob Agents Chemother 34:2169-76 (1990). Read more (PubMed: 2073107) »

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