Sulconazole nitrate, antifungal activity (ab145760)

Overview

  • Product name

    Sulconazole nitrate, antifungal activity
  • Description

    Blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles.
  • Alternative names

    • 1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
    • Exelderm
    • Sulconazole nitrate salt
  • Biological description

    Antifungal imidazole derivative. Possesses a broad spectrum of activity against dermatophytes, yeasts and some Gram-positive bacteria. Heme oxygenase (HO) inhibitor; shown to inhibit both HO-1 and HO-2 in vitro.

  • Purity

    > 99%
  • CAS Number

    61318-91-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
  • Molecular weight

    460.76
  • Molecular formula

    C18H15Cl3N2S.HNO3
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Kinobe RT  et al. Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. J Pharmacol Exp Ther 319:277-84 (2006). Read more (PubMed: 16807364) »
  • Fromtling RA Overview of medically important antifungal azole derivatives. Clin Microbiol Rev 1:187-217 (1988). Read more (PubMed: 3069196) »
  • Benfield P & Clissold SP Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs 35:143-53 (1988). Read more (PubMed: 3281821) »

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