Product nameSulconazole nitrate, antifungal activity
DescriptionBlocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles.
- Sulconazole nitrate salt
Antifungal imidazole derivative. Possesses a broad spectrum of activity against dermatophytes, yeasts and some Gram-positive bacteria. Heme oxygenase (HO) inhibitor; shown to inhibit both HO-1 and HO-2 in vitro.
Chemical name1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Kinobe RT et al. Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. J Pharmacol Exp Ther 319:277-84 (2006). Read more (PubMed: 16807364) »
- Fromtling RA Overview of medically important antifungal azole derivatives. Clin Microbiol Rev 1:187-217 (1988). Read more (PubMed: 3069196) »
- Benfield P & Clissold SP Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs 35:143-53 (1988). Read more (PubMed: 3281821) »