Sulfamonomethoxine, dihydropteroate synthetase inhibitor (ab144808)

Overview

  • Product name

    Sulfamonomethoxine, dihydropteroate synthetase inhibitor
  • Description

    Competitive dihydropteroate synthetase inhibitor
  • Biological description

    Competitive dihydropteroate synthetase inhibitor. Inhibits folic acid synthesis. Shows antithyroid and antiparasitic effects in vivo. Orally active.
  • CAS Number

    1220-83-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
  • Molecular weight

    280.30
  • Molecular formula

    C11H12N4O3S
  • PubChem identifier

    5332
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=NC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Xu GJ  et al. Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro. Braz J Med Biol Res 47:637-45 (2014). Read more (PubMed: 25003544) »
  • Ishih A  et al. A potent antimalarial activity of Hydrangea macrophylla var. Otaksa leaf extract against Plasmodium yoelii 17XL in mice. Parasitol Int 50:33-9 (2001). Read more (PubMed: 11267930) »
  • Takayama S  et al. Antithyroid effects of propylthiouracil and sulfamonomethoxine in rats and monkeys. Toxicol Appl Pharmacol 82:191-9 (1986). Read more (PubMed: 2418534) »

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