Sulfanilamide, Competitive dihydropteroate synthetase inhibitor (ab143114)

Overview

  • Product name

    Sulfanilamide, Competitive dihydropteroate synthetase inhibitor
  • Description

    Competitive dihydropteroate synthetase inhibitor. PABA analog.
  • Biological description

    Competitive dihydropteroate synthetase inhibitor. PABA analog. Inhibits folic acid synthesis. Shows bacterostatic effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    63-74-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Aminobenzenesulfonamide
  • Molecular weight

    172.20
  • Molecular formula

    C6H8N2O2S
  • PubChem identifier

    5333
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=CC=C(C=C1)S(N)(=O)=O)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mohamed SS  et al. Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents. Naunyn Schmiedebergs Arch Pharmacol 386:813-22 (2013). Read more (PubMed: 23708566) »
  • Ceruso M  et al. Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three ß-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem : (2013). Read more (PubMed: 24156740) »
  • Viswanathan VK  et al. Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli. J Bacteriol 177:5918-23 (1995). Read more (PubMed: 7592344) »

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