Anti-Sulfatase 1/SULF1 antibody (ab168616)

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Overview

  • Product name

    Anti-Sulfatase 1/SULF1 antibody
    See all Sulfatase 1/SULF1 primary antibodies

  • Description

    Mouse polyclonal to Sulfatase 1/SULF1

  • Host species

    Mouse

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat

  • Immunogen

    Full length protein corresponding to Human Sulfatase 1/SULF1 aa 1-871.
    Sequence:

    MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLT DDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV HNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGS YIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESI NYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN YAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVE PGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRT NKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARY QTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDK DKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEF EGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEI EALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLH PFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSLPGLTCFTHD NNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEY FDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDV GNKDGGSYDLHRGQLWDGWEG


    Database link: NP_055985

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • Sulfatase 1/SULF1 transfected 293T cell lysate.

  • General notes

     This product was previously labelled as Sulfatase 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab168616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 101 kDa.

Target

  • Function

    Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

  • Tissue specificity

    Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.

  • Sequence similarities

    Belongs to the sulfatase family.

  • Post-translational
    modifications

    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

  • Cellular localization

    Endoplasmic reticulum. Golgi apparatus > Golgi stack. Cell surface. Also localized on the cell surface.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • DSulf antibody
    • Extracellular sulfatase Sulf 1 antibody
    • Extracellular sulfatase Sulf-1 antibody
    • Extracellular sulfatase Sulf1 antibody
    • HSULF 1 antibody
    • HSulf-1 antibody
    • Neu5 antibody
    • Sulf1 antibody
    • SULF1_HUMAN antibody
    • Sulfatase FP antibody
    • Sulfated antibody
    see all

Images

  • Western blot - Anti-Sulfatase 1/SULF1 antibody (ab168616)
    Western blot - Anti-Sulfatase 1/SULF1 antibody (ab168616)
    All lanes : Anti-Sulfatase 1/SULF1 antibody (ab168616) at 1 µg/ml

    Lane 1 : Sulfatase 1/SULF1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 101 kDa

References

ab168616 has not yet been referenced specifically in any publications.

Publishing research using ab168616? Please let us know so that we can cite the reference in this datasheet.

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