Sulfosuccinimidyl oleate sodium, Fatty acid transport inhibitor (ab145039)

Overview

  • Product name

    Sulfosuccinimidyl oleate sodium, Fatty acid transport inhibitor
  • Description

    Fatty acid transport inhibitor.
  • Alternative names

    • (Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium
    • 2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic acid sodium salt
    • Oleic acid N-Hydroxysulfosuccinamide ester sodium salt
    • sulfo-N-succinimidyloleate sodium
  • Biological description

    Irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion. Impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.

  • CAS Number

    135661-44-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic acid sodium salt
  • Molecular weight

    481.58
  • Molecular formula

    C22H36NNaO7S
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Nicholls HT  et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes 60:1100-10 (2011). Read more (PubMed: 21378177) »
  • Noushmehr H  et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes 54:472-81 (2005). Read more (PubMed: 15677505) »
  • Luiken JJ  et al. Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes. Am J Physiol Endocrinol Metab 281:E704-12 (2001). Read more (PubMed: 11551846) »
  • Abumrad NA  et al. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem 268:17665-8 (1993). Read more (PubMed: 7688729) »
  • Harmon CM  et al. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport. J Membr Biol 121:261-8 (1991). Read more (PubMed: 1865490) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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