Key features and details
- Active metabolite of Sulindac. COX-1 and 2 inhibitor.
- CAS Number: 32004-67-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameSulindac sulfide, COX-1 and 2 inhibitor
DescriptionActive metabolite of Sulindac. COX-1 and 2 inhibitor.
Cell-permeable, active metabolite of Sulindac. Inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. COX-1 and 2 inhibitor (Ki values are 1.02 and 10.43 μM, respectively). Additionally, inhibits γ-secretase. Apoptosis inducer.
Chemical name(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Research Area
- Alzheimer's Disease
- Signal transduction
- Raf kinase
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120650 has not yet been referenced specifically in any publications.