Validated using a knockout cell line

Anti-Sumo 1 antibody [Y299] - ChIP Grade (ab32058)

Knockout Tested Rabbit recombinant monoclonal Sumo 1 antibody [Y299]. Validated in WB, IP, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Human. Cited in 48 publication(s).

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ab32058 has been referenced in 48 publications.

  • Sampaio EP  et al. Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function. J Allergy Clin Immunol 141:1844-1853.e2 (2018). PubMed: 28859974
  • Yuan H  et al. SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis. Mol Cancer 16:157 (2017). PubMed: 29020972
  • Zitti B  et al. Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells. Sci Rep 7:10445 (2017). WB ; Human . PubMed: 28874810
  • Wang J  et al. Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation. Neoplasia 19:961-971 (2017). PubMed: 29069627
  • Huang W  et al. SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-?B Inflammatory Signaling in Rat Mesangial Cells. Mediators Inflamm 2017:1685194 (2017). PubMed: 29038616
  • Yang WS  et al. SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. PLoS Pathog 13:e1006216 (2017). WB ; Human . PubMed: 28212444
  • Cloutier JM  et al. Mammalian meiotic silencing exhibits sexually dimorphic features. Chromosoma 125:215-26 (2016). PubMed: 26712235
  • Conn KL  et al. Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. J Virol 90:4807-26 (2016). PubMed: 26937035
  • Ghosh H  et al. Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun 7:13365 (2016). PubMed: 27819299
  • Maroui MA  et al. Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. PLoS Pathog 12:e1005834 (2016). PubMed: 27618691
  • Wang F  et al. Hypoxia regulates sumoylation pathways in intervertebral disc cells: implications for hypoxic adaptations. Osteoarthritis Cartilage 24:1113-24 (2016). PubMed: 26826302
  • Xiao Y  et al. Inhibition of CDK1 activity by sumoylation. Biochem Biophys Res Commun 478:919-23 (2016). PubMed: 27520372
  • Xiao Y  et al. Can your protein be sumoylated? A quick summary and important tips to study SUMO-modified proteins. Anal Biochem 477:95-7 (2015). PubMed: 25454506
  • Yeo AJ  et al. Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. Cell Discov 1:15025 (2015). WB, IF . PubMed: 27462424
  • Bish R  et al. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Biomolecules 5:1441-66 (2015). PubMed: 26184334
  • Chen C  et al. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Nat Commun 6:8899 (2015). PubMed: 26582366
  • Yang WS  et al. K-bZIP Mediated SUMO-2/3 Specific Modification on the KSHV Genome Negatively Regulates Lytic Gene Expression and Viral Reactivation. PLoS Pathog 11:e1005051 (2015). ChIP . PubMed: 26197391
  • Deng R  et al. Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development. Oncotarget 6:9355-69 (2015). PubMed: 25823821
  • Li W  et al. Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes. Mol Cancer 14:26 (2015). PubMed: 25644173
  • Sidik SM  et al. Shigella infection interferes with SUMOylation and increases PML-NB number. PLoS One 10:e0122585 (2015). WB . PubMed: 25848798
  • Everett RD  et al. Sequences related to SUMO interaction motifs in herpes simplex virus 1 protein ICP0 act cooperatively to stimulate virus infection. J Virol 88:2763-74 (2014). PubMed: 24352468
  • Geerts CJ  et al. Tomosyn interacts with the SUMO E3 ligase PIAS?. PLoS One 9:e91697 (2014). WB ; Human . PubMed: 24614299
  • Radko S  et al. Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth. J Virol 88:13469-81 (2014). IF ; Mouse . PubMed: 25210186
  • Katyal S  et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci 17:813-21 (2014). PubMed: 24793032
  • Kalkat M  et al. Identification of c-MYC SUMOylation by mass spectrometry. PLoS One 9:e115337 (2014). WB ; Human . PubMed: 25522242
  • Poulsen SL  et al. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. J Cell Biol 201:797-807 (2013). PubMed: 23751493
  • Vigodner M  et al. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. Hum Reprod 28:210-23 (2013). Human . PubMed: 23077236
  • Balasubramaniyan N  et al. SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes. J Biol Chem 288:13850-62 (2013). PubMed: 23546875
  • Chang PC  et al. The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation. BMC Genomics 14:824 (2013). ChIP . PubMed: 24267727
  • Glass M & Everett RD Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection. J Virol 87:2174-85 (2013). PubMed: 23221561
  • Santos A  et al. SUMOylation affects the interferon blocking activity of the influenza A nonstructural protein NS1 without affecting its stability or cellular localization. J Virol 87:5602-20 (2013). PubMed: 23468495
  • Cai Q  et al. A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency. PLoS Pathog 9:e1003750 (2013). Human . PubMed: 24278015
  • Gómez-Pastor R  et al. Trx2p-dependent regulation of Saccharomyces cerevisiae oxidative stress response by the Skn7p transcription factor under respiring conditions. PLoS One 8:e85404 (2013). WB . PubMed: 24376879
  • Ismail IH  et al. CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. Nucleic Acids Res 40:5497-510 (2012). ICC/IF ; Human . PubMed: 22402492
  • Neumeister VM  et al. Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues. J Natl Cancer Inst 104:1815-24 (2012). PubMed: 23090068
  • Stanton PG  et al. Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. PLoS One 7:e41718 (2012). IHC . PubMed: 22860010
  • Zhang LJ  et al. Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation. J Biol Chem 287:26971-88 (2012). PubMed: 22700985
  • Plant LD  et al. SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons. J Gen Physiol 137:441-54 (2011). ICC . PubMed: 21518833
  • De Vos WH  et al. Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. Hum Mol Genet 20:4175-86 (2011). PubMed: 21831885
  • Gibbings S  et al. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}. J Biol Chem 286:961-75 (2011). WB ; Human . PubMed: 21059659
  • Cuchet-Lourenço D  et al. SUMO Pathway Dependent Recruitment of Cellular Repressors to Herpes Simplex Virus Type 1 Genomes. PLoS Pathog 7:e1002123 (2011). ICC/IF ; Human . PubMed: 21779164
  • Boutell C  et al. A Viral Ubiquitin Ligase Has Substrate Preferential SUMO Targeted Ubiquitin Ligase Activity that Counteracts Intrinsic Antiviral Defence. PLoS Pathog 7:e1002245 (2011). WB ; Human . PubMed: 21949651
  • Pal S  et al. Influenza A virus interacts extensively with the cellular SUMOylation system during infection. Virus Res 158:12-27 (2011). WB ; Human . PubMed: 21376763
  • Cuchet D  et al. PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication. J Cell Sci 124:280-91 (2011). WB ; Human . PubMed: 21172801
  • Driscoll JJ  et al. The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome. Blood 115:2827-34 (2010). WB ; Human . PubMed: 19965618
  • Plant LD  et al. One SUMO is sufficient to silence the dimeric potassium channel K2P1. Proc Natl Acad Sci U S A 107:10743-8 (2010). ICC/IF ; Chinese hamster . PubMed: 20498050
  • Vigodner M  et al. Differential expression patterns of SUMO proteins in HL-60 cancer cell lines support a role for sumoylation in the development of drug resistance. Cell Tissue Res 336:277-86 (2009). ICC/IF ; Human . PubMed: 19326147
  • van Niekerk EA  et al. Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proc Natl Acad Sci U S A 104:12913-8 (2007). PubMed: 17646655


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