Recombinant Anti-Superoxide Dismutase 1 antibody [EPR1726] (ab79390)


  • Product name

    Anti-Superoxide Dismutase 1 antibody [EPR1726]
    See all Superoxide Dismutase 1 primary antibodies
  • Description

    Rabbit monoclonal [EPR1726] to Superoxide Dismutase 1
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Superoxide Dismutase 1 aa 50-150. The exact sequence is proprietary.
    Database link: P00441
    (Peptide available as ab195608)

  • Positive control

    • WB: HeLa, MCF7, Jurkat and HT29 cell lysates
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab79390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000. Detects a band of approximately 16 kDa (predicted molecular weight: 16 kDa).

For unpurified, use 1/100000 - 1/200000.


  • Function

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
  • Involvement in disease

    Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
  • Sequence similarities

    Belongs to the Cu-Zn superoxide dismutase family.
  • Post-translational

    Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
    The ditryptophan cross-link at Trp-33 is reponsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
  • Cellular localization

    Cytoplasm. The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
  • Information by UniProt
  • Database links

  • Alternative names

    • ALS antibody
    • ALS1 antibody
    • Amyotrophic lateral sclerosis 1 adult antibody
    • Cu/Zn SOD antibody
    • Cu/Zn superoxide dismutase antibody
    • Epididymis secretory protein Li 44 antibody
    • HEL S 44 antibody
    • Homodimer antibody
    • hSod1 antibody
    • Indophenoloxidase A antibody
    • IPOA antibody
    • Mn superoxide dismutase antibody
    • SOD antibody
    • SOD soluble antibody
    • SOD1 antibody
    • SOD2 antibody
    • SODC antibody
    • SODC_HUMAN antibody
    • Superoxide dismutase [Cu-Zn] antibody
    • Superoxide dismutase 1 antibody
    • Superoxide dismutase 1 soluble antibody
    • Superoxide dismutase Cu Zn antibody
    • Superoxide dismutase cystolic antibody
    see all


  • All lanes : Anti-Superoxide Dismutase 1 antibody [EPR1726] (ab79390) at 1/10000 dilution (purified)

    Lane 1 : HeLa cell lysate
    Lane 2 : MCF7 cell lysate
    Lane 3 : Jurkat cell lysate
    Lane 4 : HT-29 cell lysate
    Lane 5 : T47-D cell lysate
    Lane 6 : A431 cell lysate

    Lysates/proteins at 20 µg per lane.

    All lanes : HRP goat anti-rabbit IgG (H+L) at 1/50000 dilution

    Predicted band size: 16 kDa
    Observed band size: 18 kDa
    why is the actual band size different from the predicted?

    Blocking buffer: 5% NFDM/TBST
    Dilution buffer: 5% NFDM/TBST

  • All lanes : Anti-Superoxide Dismutase 1 antibody [EPR1726] (ab79390) at 1/200000 dilution (unpurified)

    Lane 1 : HeLa cell lysate
    Lane 2 : MCF7 cell lysate
    Lane 3 : Jurkat cell lysate
    Lane 4 : HT29 cell lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size: 16 kDa
    Observed band size: 16 kDa


This product has been referenced in:

  • Maugeri G  et al. Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase-activating polypeptide in an in vitro model of amyotrophic lateral sclerosis. J Cell Physiol 234:5203-5214 (2019). Read more (PubMed: 30238989) »
  • Killoy KM  et al. Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WTover-expressing mice. Exp Neurol 302:129-135 (2018). Read more (PubMed: 29307609) »
See all 8 Publications for this product

Customer reviews and Q&As

1-2 of 2 Q&A


Unfortunately, we don't have data regarding the amount of SOD1 that can be pulled down via an IP with this antibody.
We used our standard IP protocol which can be found at the URL below:

Read More


Our cross reactivity recommendations for 1926-1 and 2582-1 are based off of Western blot analysis only. We do not recommend either product for detection of mouse SOD1 as we did not obtain any staining in WB with 2582-1, and we obtained non-specific staining only with 1926-1. There is 78% homology between the immunogen sequence (which is the same for both products) and mouse SOD1. Based on these results, we do not predict that either antibody would work in ICC/IF for mouse samples.
I've attached the western blot image for 2582-1 in mouse.

Read More

For licensing inquiries, please contact

Sign up