Recombinant
RabMAb

Anti-Superoxide Dismutase 3 / EC-SOD antibody [EPR10860] (ab171738)

Overview

  • Product name
    Anti-Superoxide Dismutase 3 / EC-SOD antibody [EPR10860]
    See all Superoxide Dismutase 3 / EC-SOD primary antibodies
  • Description
    Rabbit monoclonal [EPR10860] to Superoxide Dismutase 3 / EC-SOD
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
    Unsuitable for: ICC/IF or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    within Human Superoxide Dismutase 3/ EC-SOD aa 200 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
    Database link: P08294

  • Positive control
    • Human fetal lung and heart lysates; Human heart and kidney tissues.
  • General notes

     

     

    Previously labelled as Superoxide Dismutase 3.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab171738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 26 kDa.
IHC-P 1/50 - 1/100.
  • Application notes
    Is unsuitable for ICC/IF or IP.
  • Target

    • Function
      Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
    • Tissue specificity
      Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
    • Sequence similarities
      Belongs to the Cu-Zn superoxide dismutase family.
    • Cellular localization
      Secreted > extracellular space. 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC SOD antibody
      • EC-SOD antibody
      • Extracellular superoxide dismutase [Cu Zn] antibody
      • Extracellular superoxide dismutase [Cu-Zn] antibody
      • Extracellular superoxide dismutase antibody
      • Extracellular superoxide dismutase precursor antibody
      • MGC20077 antibody
      • SOD 3 antibody
      • SOD3 antibody
      • SODE_HUMAN antibody
      • Superoxide Dismutase 3 antibody
      • Superoxide dismutase 3 extracellular antibody
      see all

    Images

    • Immunohistochemistry of paraffin-embedded Human kidney tissue labeling Superoxide Dismutase 3 / EC-SOD using ab171738 at 1/50 dilution.

    • Immunohistochemistry of paraffin-embedded Human heart tissue labeling Superoxide Dismutase 3 / EC-SOD using ab171738 at 1/50 dilution.

    • All lanes : Anti-Superoxide Dismutase 3 / EC-SOD antibody [EPR10860] (ab171738) at 1/1000 dilution

      Lane 1 : Human fetal lung lysate
      Lane 2 : Human fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 26 kDa

    References

    This product has been referenced in:
    • Bodega G  et al. The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles. Oxid Med Cell Longev 2017:7094781 (2017). WB ; Human . Read more (PubMed: 28642812) »
    • Kim CH Expression of extracellular superoxide dismutase protein in diabetes. Arch Plast Surg 40:517-21 (2013). WB, IHC-P ; Human . Read more (PubMed: 24086803) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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