Key features and details
- Non-selective P2 purinergic antagonist
- CAS Number: 129-46-4
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameSuramin hexasodium salt, non-selective P2 purinergic antagonist
DescriptionNon-selective P2 purinergic antagonist
Non-selective P2 purinergic antagonist (pEC50 values are 4.5 (P2X2), 5.4 (P2X5), 4.3 (P2Y2), 4.0 (P2Y4) and 4.8 (P2Y11)). Displays diverse biological actions. Shows antitumor activity, inhibits binding of multiple growth factors and additionally inhibits glutamatergic synaptic transmission.
Chemical name8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab120422, Suramin hexasodium salt, non-selective P2 purinergic antagonist
Inhibition by suramin, PPADS and DIDS significantly reduces the ATP-induced increase in extracellular H+ flux from isolated Müller cells.
(A) A representative trace from a single Müller cell shows a significant increase in H+ flux in response to 10 μM ATP that is significantly reduced by the ATP receptor blockers 200 μM PPADS and 200 μM suramin; asterisk indicates a background control reading. (B) 300 μM DIDS, which inhibits anion transport, significantly reduces the increase in H+ flux in response to 10 μM ATP. (C) Mean responses to 10 μM ATP with or without suramin and PPADS in the bath; N = 7, error bars represent SEMs. (D) Mean responses to 10 μM ATP in the presence of 300 μM DIDS (N = 6) and in the absence of DIDS, N = 5 (controls).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120422 has been referenced in 2 publications.
- Tchernookova BK et al. Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux. PLoS One 13:e0190893 (2018). PubMed: 29466379
- Min R & Nevian T Astrocyte signaling controls spike timing-dependent depression at neocortical synapses. Nat Neurosci 15:746-53 (2012). PubMed: 22446881