Overview

  • Product name

  • Description

    Rabbit polyclonal to SUV3L1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within C terminal amino acids 545-739 of Human SUV3L1 (Q8IYB8).

  • Positive control

    • PC3 whole cell lysate; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab127909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 88 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
  • Tissue specificity

    Broadly expressed.
  • Sequence similarities

    Belongs to the helicase family.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • Cellular localization

    Nucleus. Mitochondrion matrix. Mitochondrion matrix > mitochondrion nucleoid.
  • Information by UniProt
  • Database links

  • Alternative names

    • 6330443E10Rik antibody
    • ATP dependent RNA helicase SUPV3L1, mitochondrial antibody
    • ATP-dependent RNA helicase SUPV3L1 antibody
    • EC 3.6.1. antibody
    • MGC109049 antibody
    • mitochondrial antibody
    • OTTHUMP00000019719 antibody
    • S. Cerevisiae suppressor of var 1 3 like 1 antibody
    • suppressor of var1 (S.cerevisiae) 3 like 1 antibody
    • Suppressor of var1 3 like 1 (S. cerevisiae) antibody
    • Suppressor of var1 3 like 1 (S. cerevisiae)(SUV3) antibody
    • Suppressor of var1 3 like 1 antibody
    • Suppressor of var1 3 like protein 1 antibody
    • Suppressor of var1 3-like protein 1 antibody
    • SUPV 3 L 1 antibody
    • SUPV3L1 antibody
    • SUV 3 antibody
    • SUV 3 L 1 antibody
    • SUV3 antibody
    • SUV3 like protein 1 antibody
    • SUV3-like protein 1 antibody
    • SUV3_HUMAN antibody
    • SUV3L1 antibody
    see all

Images

  • Anti-SUV3L1 antibody (ab127909) at 1/1000 dilution + PC3 whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 88 kDa



    7.5% SDS PAGE
  • ab127909 at 1/500 dilution staining SUV3L1 in methanol-fixed HeLa cells by confocal Immunofluorescence. Alpha-tubulin filaments are stained in red.

References

ab127909 has not yet been referenced specifically in any publications.

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