Overview

  • Product name

  • Description

    Rabbit polyclonal to SUV420h1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC, WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptides derived from internal domains of Human SUV420h1.

Properties

Applications

Our Abpromise guarantee covers the use of ab104875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 99 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function

    Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.
  • Sequence similarities

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
    Contains 1 SET domain.
  • Cellular localization

    Nucleus. Chromosome. Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
  • Information by UniProt
  • Database links

  • Alternative names

    • CGI 85 antibody
    • CGI85 antibody
    • Histone-lysine N-methyltransferase KMT5B antibody
    • Kmt5b antibody
    • KMT5B_HUMAN antibody
    • Lysine N-methyltransferase 5B antibody
    • Lysine-specific methyltransferase 5B antibody
    • MGC118906 antibody
    • MGC118909 antibody
    • MGC21161 antibody
    • MGC703 antibody
    • Su(var)4-20 homolog 1 antibody
    • Suppressor of variegation 4 20 homolog 1 antibody
    • Suppressor of variegation 4-20 homolog 1 antibody
    • Suv4-20h1 antibody
    see all

References

ab104875 has not yet been referenced specifically in any publications.

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