The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Histone-lysine N-methyltransferase, H3 lysine-9 specific. Major histone methyltransferase. Methylates Lys-9 of histone H3. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Seems to be involved in heterochromatic gene silencing including the modification of position-effect-variegation.
There are three isoforms, isoform A and isoform B share the first 80 amino acid residues. Experimental confirmation may be lacking for some isoforms.
Krstic D et al. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS One7:e47793 (2012).
Read more (PubMed: 23082219) »