Overview

  • Product name

  • Description

    Rabbit polyclonal to SV2A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human SV2A aa 480-530 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    YASRTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL


    Database link: Q7L0J3

  • Positive control

    • Rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
  • Sequence similarities

    Belongs to the major facilitator superfamily.
  • Post-translational
    modifications

    Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
    N-glycosylated.
  • Cellular localization

    Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.
  • Information by UniProt
  • Database links

  • Alternative names

    • KIAA0736 antibody
    • OTTHUMP00000014065 antibody
    • SV2 antibody
    • Sv2a antibody
    • SV2A_HUMAN antibody
    • Synaptic vesicle glycoprotein 2 antibody
    • Synaptic vesicle glycoprotein 2A antibody
    • Synaptic vesicle protein 2a antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat brain tissue labeling SV2A with ab217333 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab217333 has not yet been referenced specifically in any publications.

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