Swainsonine, lysosomal alpha-mannosidase inhibitor (ab145240)
- Datasheet
- References
Overview
-
Product name
Swainsonine, lysosomal alpha-mannosidase inhibitor -
Description
Reversible lysosomal α-mannosidase inhibitor. Apoptotic agent. -
Biological description
Reversible lysosomal α-mannosidase inhibitor. Apoptotic agent. Induces apoptosis through mitochondrial pathway and caspase activation. Potentiates the effect of paclitaxel (ab120143). Shows tremorgenic and ataxic effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
72741-87-8 -
Chemical structure
Properties
-
Chemical name
(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-Octahydroindolizine-1,2,8-triol -
Molecular weight
173.21 -
Molecular formula
C8H15NO3 -
PubChem identifier
51683 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM, in ethanol and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O -
Source
Synthetic
-
Research areas
References
This product has been referenced in:
- Huang Y et al. Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. Int J Biol Sci 10:789-97 (2014). Read more (PubMed: 25076855) »
- Wang J et al. Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory. Toxicol Lett 232:263-270 (2014). Read more (PubMed: 25448288) »
- You N et al. Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo. Oncol Rep 28:2091-100 (2012). Read more (PubMed: 22993037) »
