Overview

  • Product name

    Swinholide A, F-actin inhibitor
  • Description

    Cell permeable, selective F-actin inhibitor
  • Biological description

    Cell permeable, selective F-actin inhibitor. Sequesters and stabilizes actin dimers. Induces actin depolymerization and apoptosis.
  • Purity

    > 97%
  • CAS Number

    95927-67-6
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1389.87
  • Molecular formula

    C78H132O20
  • PubChem identifier

    6436221
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]1C[C@H](C[C@@H](O1)CC[C@H](C)[C@@H]([C@H](C)[C@@H]2[C@H]([C@@H](C[C@@H]([C@@H]([C@H](C[C@@H]3CC=C[C@H](O3)C[C@H](C/C=C(/C=C/C(=O)O[C@@H](C([C@@H](C[C@@H]([C@@H]([C@H](C[C@@H]4CC=C[C@H](O4)C[C@H](C/C=C(/C=C/C(=O)O2)\C)O)OC)C)O)O)C)[C@@H](C)[C@H]([C@@H](C)CC[C@H]5C[C@@H](C[C@@H](O5)C)OC)O)\C)O)OC)C)O)O)C)O)OC
  • Source

    Theonella swinhoei

  • Research areas

References

This product has been referenced in:

  • Klenchin VA  et al. Structural basis of swinholide A binding to actin. Chem Biol 12:287-91 (2005). Read more (PubMed: 15797212) »
  • Saito SY  et al. Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A. J Biochem 123:571-8 (1998). Read more (PubMed: 9538245) »
  • Bubb MR  et al. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. J Biol Chem 270:3463-6 (1995). Read more (PubMed: 7876075) »

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