Overview

  • Product name

    Syk Inhibitor, B cell inhibitor
  • Description

    Potent, selective inhibitor of B cell signaling and function
  • Biological description

    Potent, selective inhibitor of B cell signaling and function. (IC50 = 14 nM) Cell permeable. Active in vitro and in vivo.
  • CAS Number

    622387-85-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3Z)-3-[(1-Methylindol-3-yl)methylidene]-2-oxo-1H-indole-5-sulfonamide
  • Molecular weight

    353.39
  • Molecular formula

    C18H15N3O3S
  • PubChem identifier

    6419747
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Spurgeon SE  et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther 344:378-87 (2013). Read more (PubMed: 23220742) »
  • Reilly MP  et al. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Blood 117:2241-6 (2011). Read more (PubMed: 21088136) »
  • Lai JY  et al. Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg Med Chem Lett 13:3111-4 (2003). Read more (PubMed: 12941345) »

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