Anti-Synapsin I antibody (ab8)
Key features and details
- Rabbit polyclonal to Synapsin I
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Synapsin I antibody
See all Synapsin I primary antibodies -
Description
Rabbit polyclonal to Synapsin I -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat -
Immunogen
Full length native protein (purified) corresponding to Cow Synapsin I.
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Positive control
- WB: Rat brain tissue lysates
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.50
Constituents: 0.24% HEPES, 0.87% Sodium chloride, 0.0001% BSA, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000. Predicted molecular weight: 80 kDa.
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Notes |
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WB
1/1000. Predicted molecular weight: 80 kDa. |
Target
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Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. -
Involvement in disease
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior. -
Sequence similarities
Belongs to the synapsin family. -
Post-translational
modificationsSubstrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cell junction > synapse. Golgi apparatus. - Information by UniProt
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Database links
- Entrez Gene: 24949 Rat
- SwissProt: P09951 Rat
- Unigene: 9923 Rat
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Alternative names
- Brain protein 4.1 antibody
- SYN 1 antibody
- SYN 1a antibody
see all
Images
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Anti-Synapsin I antibody (ab8) + Rat brain tissue lysate at 10 µg
Predicted band size: 80 kDa
Observed band size: 78 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (52)
ab8 has been referenced in 52 publications.
- Li SS et al. Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury. Neural Regen Res 17:1545-1555 (2022). PubMed: 34916440
- Gaikwad S et al. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia. Cell Rep 36:109419 (2021). PubMed: 34289368
- Fu ZW et al. The metabolite methylglyoxal-mediated gene expression is associated with histone methylglyoxalation. Nucleic Acids Res 49:1886-1899 (2021). PubMed: 33476385
- Sadek J et al. Pharmacological or genetic inhibition of iNOS prevents cachexia-mediated muscle wasting and its associated metabolism defects. EMBO Mol Med 13:e13591 (2021). PubMed: 34096686
- Held RG et al. Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry. Neuron 107:667-683.e9 (2020). PubMed: 32616470