Overview

  • Product name

    Anti-Synapsin I (phospho S603) antibody
    See all Synapsin I primary antibodies
  • Description

    Rabbit polyclonal to Synapsin I (phospho S603)
  • Host species

    Rabbit
  • Specificity

    The antibody is specific for Synapsin I phosphorylated at Ser603.
  • Tested applications

    Suitable for: Dot blot, WBmore details
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    This antibody was developed against synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser603 of rat Synapsin I.

  • General notes

    Aliquots may be taken without freeze/thawing due to the presence of 50% glycerol.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.50
    Constituents: 0.238% HEPES, 0.87% Sodium chloride, 0.01% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    The antibody was purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab13879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot 1/1000.
WB 1/1000. Predicted molecular weight: 84.6 kDa.

Target

  • Function

    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • Involvement in disease

    Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • Sequence similarities

    Belongs to the synapsin family.
  • Post-translational
    modifications

    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

Images

  • Right lane-ab13879 at 1/1000 dilution detecting synapsin I by Western blot. Left lane-Peptide block. Right lane-ab13879 at 1/1000 dilution detecting synapsin I by Western blot. Left lane-Peptide block.

References

This product has been referenced in:

  • Arias-Cavieres A  et al. Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction. Front Cell Neurosci 12:403 (2018). Read more (PubMed: 30459562) »
  • Arias-Cavieres A  et al. Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats. Front Mol Neurosci 11:429 (2018). Read more (PubMed: 30534053) »
See all 2 Publications for this product

Customer reviews and Q&As

Question
Answer

Thank you for your enquiry. I can confirm that the immunogen for this product is phospho-Ser603 of rat Synapsin I. I sincerely apologize that we had a typing error on the datasheet and rest assured that it has now been corrected. Thank you again for pointing this out to us as.

Read More

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