Overview

  • Product name

    Anti-Synapsin I (phospho S9) antibody
    See all Synapsin I primary antibodies
  • Description

    Rabbit polyclonal to Synapsin I (phospho S9)
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Synapsin I (phospho S9). Phospho specific peptide corresponding to residues surrounding Serine 9 of Human Synapsin I.
    Database link: P17600

  • Positive control

    • Mouse brain tissue extract; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab194778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 74 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Function

    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • Involvement in disease

    Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • Sequence similarities

    Belongs to the synapsin family.
  • Post-translational
    modifications

    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

Images

  • Anti-Synapsin I (phospho S9) antibody (ab194778) at 1/500 dilution + Mouse brain tissue extract

    Predicted band size: 74 kDa

  • Immunofluorescent analysis of methanol-fixed HeLa cells labeling Synapsin I (phospho S9) with ab194778 at 1/100 dilution.

References

ab194778 has not yet been referenced specifically in any publications.

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