Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol, 59% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab220345 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 1 - 4 µg/ml.
Fixation/Permeabilization: PFA/Triton X-100.
FunctionHas an actin-binding and actin-bundling activity.
Tissue specificitySkeletal muscle-specific.
Sequence similaritiesBelongs to the synaptopodin family.
Contains 1 PDZ (DHR) domain.
Cellular localizationNucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin.
- Information by UniProt
- DKFZp686G051 antibody
- Genethonin 2 antibody
- Genethonin-2 antibody
This product has been referenced in:
- Cai X et al. Silence of IGFBP7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes. Exp Ther Med 16:1095-1102 (2018). Read more (PubMed: 30112052) »
- Li Y et al. Overexpression of KLF5 inhibits puromycin-induced apoptosis of podocytes. Mol Med Rep 18:3843-3849 (2018). Read more (PubMed: 30106142) »