Overview

  • Product name

    Anti-SynCAM/CADM1 antibody - N-terminal
    See all SynCAM/CADM1 primary antibodies
  • Description

    Rabbit polyclonal to SynCAM/CADM1 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human SynCAM/CADM1 aa 73-92 (N terminal).
    Sequence:

    VIQLLNPNRQTIYFRDFRPL


    Database link: Q9BY67

  • Positive control

    • A549, Jurkat, Raji and HeLa whole cell lysates.
  • General notes

     This product was previously labelled as SynCAM

     

Properties

Applications

Our Abpromise guarantee covers the use of ab191046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml.

Target

  • Function

    Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
  • Sequence similarities

    Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
  • Cellular localization

    Cell membrane. Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
  • Information by UniProt
  • Database links

  • Alternative names

    • BL2 antibody
    • Cadm1 antibody
    • CADM1_HUMAN antibody
    • Cell adhesion molecule 1 antibody
    • DKFZp686F1789 antibody
    • IgSF4 antibody
    • IGSF4A antibody
    • Immunoglobulin superfamily member 4 antibody
    • MGC149785 antibody
    • MGC51880 antibody
    • NECL-2 antibody
    • NECL2 antibody
    • Nectin like 2 antibody
    • Nectin-like protein 2 antibody
    • RA175 antibody
    • SgIGSF antibody
    • Spermatogenic immunoglobulin superfamily antibody
    • ST17 antibody
    • sTSLC 1 antibody
    • Synaptic cell adhesion molecule antibody
    • SynCAM antibody
    • SynCAM1 antibody
    • TSLC-1 antibody
    • TSLC1 antibody
    • Tumor suppressor in lung cancer 1 antibody
    see all

Images

  • All lanes : Anti-SynCAM/CADM1 antibody - N-terminal (ab191046) at 0.5 µg/ml

    Lane 1 : A549 whole cell lysate
    Lane 2 : Jurkat whole cell lysate
    Lane 3 : Raji whole cell lysate
    Lane 4 : HeLa whole cell lysate

    Lysates/proteins at 40 µg per lane.

    Additional bands at: 60 kDa. We are unsure as to the identity of these extra bands.

References

ab191046 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191046.
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