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Anti-SynGAP antibody (ab126871)

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Western blot - Anti-SynGAP antibody (ab126871)

    Key features and details

    • Goat polyclonal to SynGAP
    • Suitable for: WB
    • Reacts with: Mouse
    • Isotype: IgG

    Get better batch-to-batch reproducibility with a recombinant antibody

    Product image
    Anti-SynGAP antibody [EPR2883Y] (ab77235)
    • Research with confidence – consistent and reproducible results with every batch
    • Long-term and scalable supply – powered by recombinant technology for fast production
    • Success from the first experiment – confirmed specificity through extensive validation
    • Ethical standards compliant – production is animal-free

    Overview

    • Product name

      Anti-SynGAP antibody
      See all SynGAP primary antibodies
    • Description

      Goat polyclonal to SynGAP
    • Host species

      Goat
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Mouse
      Predicted to work with: Rat, Human
    • Immunogen

      Synthetic peptide:

      DEDEIHPLLIRDR-C

      (with a Cysteine residue linker), corresponding to N terminal amino acids 60-72 of Human SynGAP (NP_006763.2; Q96PV0).
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Mouse Brain lysate
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 0.5% BSA, 99% Tris buffered saline
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Purification notes

      Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurotransmission
      • Intracellular Signaling
      • Adapters
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Synapse marker

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Positive Controls

      • Mouse brain tissue lysate - total protein (ab30151)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab126871 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 148 kDa.

    1 hour primary incubation is recommended for this product.

    Notes
    WB
    Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 148 kDa.

    1 hour primary incubation is recommended for this product.

    Target

    • Function

      Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
    • Involvement in disease

      Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients.
    • Sequence similarities

      Contains 1 C2 domain.
      Contains 1 PH domain.
      Contains 1 Ras-GAP domain.
    • Post-translational
      modifications

      Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.
    • Target information above from: UniProt accession Q96PV0 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 8831 Human
      • Entrez Gene: 240057 Mouse
      • Entrez Gene: 192117 Rat
      • Omim: 603384 Human
      • SwissProt: Q96PV0 Human
      • SwissProt: Q9QUH6 Rat
      • Unigene: 586264 Human
      • Unigene: 9908 Rat
      • Alternative names

        • DKFZp761G1421 antibody
        • KIAA1938 antibody
        • MRD5 antibody
        • Neuronal RasGAP antibody
        • OTTHUMP00000064825 antibody
        • p135 SynGAP antibody
        • Ras GTPase activating protein SynGAP antibody
        • Ras GTPase-activating protein SynGAP antibody
        • RASA 1 antibody
        • RASA 5 antibody
        • RASA1 antibody
        • RASA5 antibody
        • SYGP1_HUMAN antibody
        • Synaptic Ras GAP 1 antibody
        • Synaptic Ras GTPase activating protein 1 antibody
        • Synaptic Ras GTPase activating protein 1 homolog antibody
        • Synaptic Ras GTPase activating protein 135kDa antibody
        • Synaptic Ras GTPase activating protein antibody
        • Synaptic Ras GTPase-activating protein 1 antibody
        • Synaptic Ras-GAP 1 antibody
        • SYNGAP 1 antibody
        • SYNGAP1 antibody
        see all

      Images

      • Western blot - Anti-SynGAP antibody (ab126871)
        Western blot - Anti-SynGAP antibody (ab126871)
        Anti-SynGAP antibody (ab126871) at 2 µg/ml + Mouse Brain lysate at 35 µg

        Developed using the ECL technique.

        Predicted band size: 148 kDa


        Exposure time: 1 hour

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab126871? Please let us know so that we can cite the reference in this datasheet.

      ab126871 has not yet been referenced specifically in any publications.

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