- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-SynGAP antibody
See all SynGAP primary antibodies -
DescriptionGoat polyclonal to SynGAP
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Host speciesGoat
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Mouse
Predicted to work with: Rat, Human
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Immunogen
Synthetic peptide:
DEDEIHPLLIRDR-C
(with a Cysteine residue linker), corresponding to N terminal amino acids 60-72 of Human SynGAP (NP_006763.2; Q96PV0). -
Positive control
- Mouse Brain lysate
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
PurityImmunogen affinity purified
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Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab126871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 148 kDa. |
Target
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FunctionMajor constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
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Involvement in diseaseDefects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients.
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Sequence similaritiesContains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain. -
Post-translational
modificationsPhosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. - Information by UniProt
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Database links
- Entrez Gene: 8831 Human
- Entrez Gene: 240057 Mouse
- Entrez Gene: 192117 Rat
- Omim: 603384 Human
- SwissProt: Q96PV0 Human
- SwissProt: Q9QUH6 Rat
- Unigene: 586264 Human
- Unigene: 9908 Rat
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Alternative names
- DKFZp761G1421 antibody
- KIAA1938 antibody
- MRD5 antibody
see all
Images
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Western blot - Anti-SynGAP antibody (ab126871)Anti-SynGAP antibody (ab126871) at 2 µg/ml + Mouse Brain lysate at 35 µg
Developed using the ECL technique.
Predicted band size: 148 kDa
Exposure time: 1 hour
Protocols
References
ab126871 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"