Synthetic Human Macrophage Inflammatory Protein 1 alpha / CCL3 (Biotin) (ab176081)

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Description

  • Product name

    Synthetic Human Macrophage Inflammatory Protein 1 alpha / CCL3 (Biotin)
    See all Macrophage Inflammatory Protein 1 alpha / CCL3 proteins and peptides

  • Expression system

    Synthetic

  • Accession

    P10147

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Synthetic

    • Species

      Human

    • Sequence

      ASLAADTP TACCFSYTSR QIPQNFIADY FETSSQCSKP GVIFLTKRSR QVCADPSEEW VQKYVSDLEL SA-Linker-K(Biotin)

    • Predicted molecular weight

      8 kDa

    • Amino acids

      23 to 92

    • Additional sequence information

      Mature protein. Linker used is 8-amino-3,6-dioxaoctanoic acid.

  • Conjugation

    Biotin

Specifications

Our Abpromise guarantee covers the use of ab176081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

  • Reconstitution
    It is recommended vials be centrifuged prior to opening. Water can be used to prepare stock solutions of 20 µmol.L-1. Stock solutions with up to 30% DMSO/water can also be prepared.

General Info

  • Alternative names

    • C C motif chemokine 3
    • CCL 3
    • CCL3
    • CCL3_HUMAN
    • Chemokine (C C motif) ligand 3
    • Chemokine C C motif ligand 3
    • Chemokine ligand 3
    • G0/G1 switch regulatory protein 19 1
    • G0/G1 switch regulatory protein 19-1
    • G0S19 1
    • G0S19 1 protein
    • Heparin binding chemotaxis protein
    • L2G25B
    • LD78 alpha
    • LD78-alpha(4-69)
    • LD78alpha
    • Macrophage inflammatory protein 1 alpha
    • Macrophage inflammatory protein 1-alpha
    • macrophage inflammatory protein 1a
    • MIP 1 alpha
    • MIP 1A
    • MIP-1-alpha
    • MIP-1-alpha(4-69)
    • MIP1 alpha
    • MIP1A
    • PAT 464.1
    • SCYA 3
    • SCYA3
    • SIS alpha
    • SIS beta
    • SIS-beta
    • Small inducible cytokine A3
    • small inducible cytokine A3 (homologous to mouse Mip-1a)
    • Small-inducible cytokine A3
    • Tonsillar lymphocyte LD78 alpha protein
    see all

  • Function

    Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

  • Sequence similarities

    Belongs to the intercrine beta (chemokine CC) family.

  • Post-translational
    modifications

    N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab176081 has not yet been referenced specifically in any publications.

Publishing research using ab176081? Please let us know so that we can cite the reference in this datasheet.

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