Name: Synthetic Human MCP2 protein (Animal Free)
SKU: ab175171

Product name

Synthetic Human MCP2 protein (Animal Free)
See all MCP2 proteins and peptides
Protein length

Protein fragment
Description

Synthetic Human MCP2 protein

Our Abpromise guarantee covers the use of ab175171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Stability and Storage

Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Information available upon request.
Reconstitution

It is recommended vials be centrifuged prior to opening. Water can be used to prepare stock solutions of 20 µmol.L-1. Stock solutions with up to 30% DMSO/water can also be prepared.

Alternative names
- Ccl8
- CCL8_HUMAN
- HC14
- MCP-2
- MCP-2(6-76)
- Monocyte chemoattractant protein 2
- Monocyte chemotactic protein 2
- SCYA10
- SCYA8
- Small-inducible cytokine A8
see all
Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
Tissue specificity

Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.
Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.
Post-translational
modifications

N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Cellular localization

Secreted.
Target information above from: UniProt accession P80075 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

ab175171 has not yet been referenced specifically in any publications.

Publishing research using ab175171? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Synthetic Human MCP2 protein (Animal Free) (ab175171)