Synthetic Human MCP2 protein (Animal Free) (ab175171)
- Datasheet
- References
- Protocols
Description
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Product name
Synthetic Human MCP2 protein (Animal Free)
See all MCP2 proteins and peptides -
Expression system
Synthetic -
Accession
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Protein length
Protein fragment -
Animal free
Yes -
Nature
Synthetic -
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Species
Human -
Sequence
QPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKE VCADPKERWVRDSMKHLDQI FQNLK -
Predicted molecular weight
9 kDa -
Amino acids
24 to 98
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Description
Synthetic Human MCP2 protein
Specifications
Our Abpromise guarantee covers the use of ab175171 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
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Form
Lyophilised -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Information available upon request.
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ReconstitutionIt is recommended vials be centrifuged prior to opening. Water can be used to prepare stock solutions of 20 µmol.L-1. Stock solutions with up to 30% DMSO/water can also be prepared.
General Info
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Alternative names
- Ccl8
- CCL8_HUMAN
- HC14
see all -
Function
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. -
Tissue specificity
Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsN-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. -
Cellular localization
Secreted. - Information by UniProt
Datasheets and documents
References
ab175171 has not yet been referenced specifically in any publications.
