Overview

  • Product name

    Anti-Syntrophin alpha 1 antibody
    See all Syntrophin alpha 1 primary antibodies
  • Description

    Rabbit polyclonal to Syntrophin alpha 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Syntrophin alpha 1 aa 50-100. The exact sequence is proprietary.
    Database link: Q13424

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: Tris citrate/phosphate

    pH 7 to 8
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab241159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-biphosphate.
    • Tissue specificity

      High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.
    • Involvement in disease

      Defects in SNTA1 are the cause of long QT syndrome type 12 (LQT12) [MIM:612955]. A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
    • Sequence similarities

      Belongs to the syntrophin family.
      Contains 1 PDZ (DHR) domain.
      Contains 2 PH domains.
      Contains 1 SU (syntrophin unique) domain.
    • Domain

      The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-biphosphate.
      The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.
      The SU domain binds calmodulin in a calcium-dependent manner.
    • Post-translational
      modifications

      Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD.
    • Cellular localization

      Cell membrane > sarcolemma. Cell junction. Cytoplasm > cytoskeleton. In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
    • Information by UniProt
    • Database links

    • Alternative names

      • 59 kDa dystrophin-associated protein A1 acidic component 1 antibody
      • Acidic alpha 1 syntrophin antibody
      • Alpha 1 syntrophin antibody
      • Alpha-1-syntrophin antibody
      • dJ1187J4.5 antibody
      • Dystrophin associated protein A1 59kDa acidic component antibody
      • LQT12 antibody
      • OTTHUMP00000030650 antibody
      • Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody
      • SNT1 antibody
      • Snta1 antibody
      • SNTA1_HUMAN antibody
      • Syntrophin 1 antibody
      • Syntrophin-1 antibody
      • TACIP1 antibody
      see all

    Images

    • All lanes : Anti-Syntrophin alpha 1 antibody (ab241159) at 0.4 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Exposure time: 30 seconds


      Prepared using NETN lysis buffer.

    References

    ab241159 has not yet been referenced specifically in any publications.

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