Overview

  • Product name

  • Description

    Rabbit polyclonal to SYT1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SYT1 aa 307-311 conjugated to keyhole limpet haemocyanin.
    Sequence:

    GLSDP


    Database link: NP_001129277.1

  • Positive control

    • HeLa cells; Mouse brain and Rat brain tissue extracts

Properties

Applications

Our Abpromise guarantee covers the use of ab131551 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 47 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Function

    May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
  • Sequence similarities

    Belongs to the synaptotagmin family.
    Contains 2 C2 domains.
  • Domain

    The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
    The second C2 domain mediates interaction with SV2A and STN2.
  • Cellular localization

    Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. Cytoplasm. Synaptic vesicles and chromaffin granules.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp781D2042 antibody
    • FLJ42519 antibody
    • p65 antibody
    • SVP65 antibody
    • Synaptotagmin 2 antibody
    • Synaptotagmin I antibody
    • Synaptotagmin II antibody
    • Synaptotagmin-1 antibody
    • SYT antibody
    • Syt1 antibody
    • SYT1_HUMAN antibody
    • Syt2 antibody
    • SytI antibody
    see all

Images

  • Immunofluorescent analysis of methanol-fixed HeLa cells labelling SYT1 with ab131551 at 1/100 dilution.

  • All lanes : Anti-SYT1 antibody (ab131551) at 1/500 dilution

    Lane 1 : Mouse brain tissue extract
    Lane 2 : Rat brain tissue extract

    Predicted band size: 47 kDa

References

ab131551 has not yet been referenced specifically in any publications.

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