Overview

  • Product name
    T0901317, LXR agonist
  • Description
    Potent, non-selective LXR agonist
  • Biological description
    Potent, non-selective LXR agonist (EC50 = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo.
  • Purity
    > 99%
  • CAS Number
    293754-55-9
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
  • Molecular weight
    481.33
  • Molecular formula
    C17H12F9NO3S
  • PubChem identifier
    447912
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 100mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=S(=O)(N(CC(F)(F)F)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c2ccccc2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Gao M & Liu D The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance. AAPS J 15:258-66 (2013). Read more (PubMed: 23180161) »
  • Baranowski M  et al. Liver X receptor agonist T0901317 enhanced peroxisome proliferator-activated receptor-delta expression and fatty acid oxidation in rat skeletal muscle. J Physiol Pharmacol 64:289-97 (2013). Read more (PubMed: 23959725) »
  • Zhuang J  et al. Regulation of prostaglandin F2a against ß amyloid clearance and its inflammation induction through LXR/RXR heterodimer antagonism in microglia. Prostaglandins Other Lipid Mediat : (2013). Read more (PubMed: 24076168) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142808.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up