Overview

  • Product name

  • Description

    Rabbit polyclonal to TAB2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human TAB2 aa 302-368.
    Sequence:

    GSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSST SSSVNSQTLNRNQPTVY


    Database link: Q9NYJ8

  • Positive control

    • ICC/IF: MCF7 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab222214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function

    Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
  • Tissue specificity

    Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
  • Involvement in disease

    Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).
  • Sequence similarities

    Contains 1 CUE domain.
    Contains 1 RanBP2-type zinc finger.
  • Post-translational
    modifications

    Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
    Phosphorylated.
  • Cellular localization

    Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.
  • Information by UniProt
  • Database links

  • Alternative names

    • CHTD2 antibody
    • FLJ21885 antibody
    • KIAA0733 antibody
    • MAP3K7IP2 antibody
    • Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody
    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody
    • OTTHUMP00000040125 antibody
    • TAB 2 antibody
    • TAB-2 antibody
    • Tab2 antibody
    • TAB2_HUMAN antibody
    • TAK1 binding protein 2 antibody
    • TAK1-binding protein 2 antibody
    • TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody
    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody
    • TGF-beta-activated kinase 1-binding protein 2 antibody
    see all

Images

  • PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for TAB2 (green) using ab222214 at 4 µg/ml in ICC/IF.

References

This product has been referenced in:

  • Wan J  et al. Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model. Cell Death Dis 10:303 (2019). Read more (PubMed: 30944299) »
See 1 Publication for this product

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