Overview

  • Product name

  • Description

    Goat polyclonal to TAB3
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Hamster
  • Immunogen

    Synthetic peptide:

    C-HSPDDNRMNRN

    (with a Cysteine residue linker), corresponding to internal sequence amino acids 59-69 of Human TAB3 (NP_690000.2).

  • Positive control

    • IHC-P: Human Thyroid tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab134806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
  • Tissue specificity

    Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
  • Sequence similarities

    Contains 1 CUE domain.
    Contains 1 RanBP2-type zinc finger.
  • Post-translational
    modifications

    Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
  • Information by UniProt
  • Database links

  • Alternative names

    • MAP3K7IP 3 antibody
    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody
    • NAP1 antibody
    • NF-kappa-B-activating protein 1 antibody
    • NFkB activating protein 1 antibody
    • TAB-3 antibody
    • Tab3 antibody
    • TAB3_HUMAN antibody
    • TAK1 binding protein 3 antibody
    • TAK1-binding protein 3 antibody
    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 antibody
    • TGF-beta-activated kinase 1-binding protein 3 antibody
    see all

Images

  • Immunohistochemistry analysis of Formalin fixed and Paraffin Embedded (IHC-P) Human Thyroid tissue labelling TAB3 with ab134806 at 3.75 µg/ml.

References

ab134806 has not yet been referenced specifically in any publications.

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