Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 8.00
Preservative: 0.05% Sodium azide
Constituents: 2.42% Tris, 0.0292% EDTA, 30% Glycerol, 8.7% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab17915 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 125 and 55 kDa (predicted molecular weight: 90 kDa, there are several other isoforms).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionLikely involved in the processes that promote cell division prior to the formation of differentiated tissues.
Tissue specificityIsoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
Sequence similaritiesBelongs to the TACC family.
Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.
Developmental stageExpressed at high level during early embryogenesis.
modificationsIsoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationCytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome. Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.
- Information by UniProt
- DKFZp686K18126 antibody
- Ga 55 antibody
- Ga55 antibody
ab17915 has not yet been referenced specifically in any publications.