Overview

  • Product name

    Anti-TACI antibody [1A1]
    See all TACI primary antibodies
  • Description

    Rat monoclonal [1A1] to TACI
  • Host species

    Rat
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human TACI. (TACI-transfected RBL cells).

  • Positive control

    • Flow Cyt: Human peripheral blood.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.0975% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    Purity > 95% (by SDS-PAGE).
  • Clonality

    Monoclonal
  • Clone number

    1A1
  • Isotype

    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab234225 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Target

  • Function

    Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
  • Tissue specificity

    Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.
  • Involvement in disease

    Defects in TNFRSF13B are the cause of immunodeficiency common variable type 2 (CVID2) [MIM:240500]. CVID2 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    Defects in TNFRSF13B are a cause of immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]. Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
  • Sequence similarities

    Contains 2 TNFR-Cys repeats.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD 267 antibody
    • CD267 antibody
    • CD267 antigen antibody
    • CVID antibody
    • CVID2 antibody
    • FLJ39942 antibody
    • MGC133214 antibody
    • MGC39952 antibody
    • OTTHUMP00000065442 antibody
    • TNFRSF 13B antibody
    • TNFRSF 14B antibody
    • TNFRSF13B antibody
    • TNFRSF13B protein antibody
    • TNFRSF14B antibody
    • TR13B_HUMAN antibody
    • Transmembrane activator and CAML interactor antibody
    • Tumor necrosis factor receptor 13B antibody
    • Tumor necrosis factor receptor superfamily member 13B antibody
    see all

Images

  • Flow cytometric analysis of human peripheral blood labeling TACI with ab234225, followed by Donkey anti-rat APC. Surface staining, gated on leukocytes.

References

ab234225 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab234225.
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