Overview

  • Product name

    Anti-Tafazzin / TAZ antibody
    See all Tafazzin / TAZ primary antibodies
  • Description

    Rabbit polyclonal to Tafazzin / TAZ
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee, Baboon, Macaque monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human Tafazzin/ TAZ aa 100-200 conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab124617)

  • Positive control

    • This antibody gave a positive signal in both Human and Mouse Heart tissue lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab105104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

Target

  • Function

    Some isoforms may be involved in cardiolipin (CL) metabolism.
  • Tissue specificity

    High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.
  • Involvement in disease

    Barth syndrome
  • Sequence similarities

    Belongs to the taffazin family.
  • Domain

    The hydrophilic domain may serve as an exposed loop interacting with other proteins.
  • Cellular localization

    Cytoplasm and Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Barth syndrome antibody
    • BTHS antibody
    • Cardiomyopathy dilated 3A (X linked) antibody
    • CMD3A antibody
    • EFE antibody
    • EFE2 antibody
    • Endocardial fibroelastosis 2 antibody
    • G4.5 antibody
    • LVNCX antibody
    • Protein G4.5 antibody
    • Tafazzin antibody
    • TAZ antibody
    • TAZ protein antibody
    • TAZ_HUMAN antibody
    • Taz1 antibody
    see all

Images

  • All lanes : Anti-Tafazzin / TAZ antibody (ab105104) at 1 µg/ml

    Lane 1 : Human heart tissue lysate - total protein (ab29431)
    Lane 2 : Heart (Mouse) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 33 kDa
    Observed band size: 33 kDa
    Additional bands at: 110 kDa, 65 kDa. We are unsure as to the identity of these extra bands.


    Exposure time: 1 minute


    Abcam recommends using milk as the blocking agent. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.

References

This product has been referenced in:

  • Chen S  et al. In vitro fertilization alters phospholipid profiles in mouse placenta. J Assist Reprod Genet N/A:N/A (2019). Read more (PubMed: 30610659) »
  • Eirin A  et al. Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension. J Am Heart Assoc 5:N/A (2016). Read more (PubMed: 27247333) »
See all 2 Publications for this product

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