Overview

  • Product name

    TAK 165, ErbB2 inhibitor
  • Description

    Potent, highly selective, irreversible ErbB2 inhibitor
  • Biological description

    Potent, highly selective, irreversible ErbB2 inhibitor (IC50 = 6 nM). Shows potent antiproliferative effects (IC50 = 5 nM, ErbB2 overexpressing cancer cell lines). Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    366017-09-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Uitdehaag JC  et al. Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs. PLoS One 10:e0125021 (2015). Read more (PubMed: 26018524) »
  • Nagasawa J  et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int J Urol 13:587-92 (2006). Read more (PubMed: 16771730) »
  • Pappas BA  et al. Neonatal brain dopamine depletion and the cortical and behavioral consequences of enriched postweaning environment. Pharmacol Biochem Behav 42:741-8 (1992). Read more (PubMed: 1513856) »

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